The Notch Pathway Targets Proangiogenic Regulator Sox17 to Restrict Angiogenesis
نویسندگان
چکیده
1Graduate School of Medical Science and Engineering and 2Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea; 3Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hospital, Gwangju, 501-757, Republic of Korea; 4Transgenic Animal Model Core, University of Michigan, Ann Arbor, Michigan, 48109-5674, USA; 5Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA.
منابع مشابه
Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis.
RATIONALE The Notch pathway stabilizes sprouting angiogenesis by favoring stalk cells over tip cells at the vascular front. Because tip and stalk cells have different properties in morphology and function, their transcriptional regulation remains to be distinguished. Transcription factor Sox17 is specifically expressed in endothelial cells, but its expression and role at the vascular front rema...
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RATIONALE Vascular endothelial growth factor (VEGF) signaling is a key pathway for angiogenesis and requires highly coordinated regulation. Although the Notch pathway-mediated suppression of excessive VEGF activity via negative feedback is well known, the positive feedback control for augmenting VEGF signaling remains poorly understood. Transcription factor Sox17 is indispensable for angiogenes...
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The Notch pathway is a highly conserved signaling system that controls a diversity of growth, differentiation, and patterning processes. In growing blood vessels, sprouting of endothelial tip cells is inhibited by Notch signaling, which is activated by binding of the Notch receptor to its ligand Delta-like 4 (Dll4). Here, we show that the Notch ligand Jagged1 is a potent proangiogenic regulator...
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Angiogenesis is a coordinated process tightly regulated by the balance between Delta-like-4 (DLL4) and Jagged-1 (JAG1) in endothelial cells. Here we show that galectin-3 (gal-3), a glycan-binding protein secreted by cancer cells under hypoxic conditions, triggers sprouting angiogenesis, assisted by hypoxic changes in the glycosylation status of endothelial cells that enhance binding to gal-3. G...
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تاریخ انتشار 2014